Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone.

Treatment of gastric ulcer with carbenoxolone: antagonistic effect of spironolactone.

Controlled trials have shown that the rate of healing of gastric ulcers is increased by treatment with carbenoxolone sodium, but that fluid retention is produced as a side effect sufficiently often to limit the freedom with which the drug can be prescribed (Doll, Hill, Hutton, and Underwood, 1962; Doll, Hill, and Hutton, 1965; Horwich and Galloway, 1965). We have, therefore, sought a method of ...

Treatment of Gastric Ulcer with Carbenoxolone Sodium and Oestrogens.

Carbenoxolone sodium in the treatment of gastric ulcer with special reference to side-effects.

Serum carbenoxolone in patients with gastric and duodenal ulcer

The absorption of carbenoxolone sodium has been studied in 15 patients with gastric ulcer and eight patients with duodenal ulcer treated for four weeks. Blood levels of carbenoxolone showed a log distribution, varied markedly between patients, and were significantly higher after Biogastrone tablets (300 mg/day) than after Duogastrone capsules (200 mg/day). Serum carbenoxolone levels were simila...

Controlled comparison of cimetidine and carbenoxolone sodium in gastric ulcer.

Fifty-four outpatients with endoscopically diagnosed benign gastric ulcer were allocated at random to treatment with either cimetidine 800 mg daily for six weeks or carbenoxolone sodium 300 mg daily for one week then 150 mg daily for five weeks. Ulcers were reassessed by endoscopy at the end of the trial. The endoscopist was unaware of the treatment and did not take part in the clinical care of...